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PGE2 also sensitizes peripheral nociceptors by reducing the threshold for action potential generation an effect that converts normally innocuous stimuli (such as gentle touch or mild temperature changes) into painful stimuli, contributing to the hyperalgesia of inflamed tissues

doi: 10.1128/MMBR.64.4.655-671.2000.Updated 208 WangY

Each injection is going to have its own dosage instructions, and this is what should be followed by individuals who are using it

And for researchers interested in potential neurological effects , the nasal route offers something injections cannot: a more direct pathway to the central nervous system