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Across the range of ionic conditions tested, the RS- and RSC-bound arrays showed similar scattering profiles that differed consistently from those of WT H1.4-bound arrays (Supplementary Fig

& Scheller, E

6, 7 Because all newborn screening programs in the United States and many other countries worldwide include biotinidase deficiency in their panel of screened conditions, there is an increased need to define and standardize laboratory approaches for enzymatic biotinidase testing, to delineate situations for which follow-up molecular testing is warranted, and to characterize variables that can influence test performance and interpretation of results

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