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[14] PUFA-fortified foods available on the market have been increasing since epidemiological and clinical researches have revealed possible effects of PUFA on brain development and curative and/or preventive effects on cardiovascular disease

The most widely accepted first-line systemic treatments for moderate-to-severe cutaneous disease are MMF and methotrexate, although other previously mentioned therapies may also be used

Research indicates its potential to interact with beta-adrenergic pathways, amplifying beta(3)-AR receptor sensitivity and enhancing fat oxidation and energy expenditure without inducing IGF-1 production

In contrast, the high prevalence of HbE in regions historically endemic for P.v suggests it may have evolved under pressure from this species, particularly in parts of Southeast Asia (Supplement Fig