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In a separate investigation, the inclusion of vitamin C was found to not only hinder the rise of reactive oxygen species count and decrease the likelihood of DNA damage and apoptosis, but also successfully prevent carboplatin from reducing the mouse oocytes' sperm binding ability and potential for fertilisation by interfering with their meiotic mechanism ( 8 Summary and outlook This paper discusses the chemical types and structures of platinum-based antitumour drugs, their mechanisms of action, routes of administration, and potential reproductive, genotoxic, and embryotoxic effects

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10.1007/128_2014_571 45 GeorgiadisD.MpakaliA.KoumantouD.StratikosE