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Furthermore, women tend to show greater cognitive resilience in preclinical stages, followed by a disproportionately accelerated cognitive decline and neurodegeneration after the onset of MCI and dementiaresulting in more severe multidomain impairment than men despite comparable amyloid burden (213, 218221)

And, uh, your, you first start to get, your insulin levels start to [00:13:00] elevate, and then you start to get insulin resistance, and then your glucose itself will start to elevate and they get pre-diabetes

doi: 10.3389/fnins.2018.00073 132 DuringMJCaoLZuzgaDSFrancisJSFitzsimonsHLJiaoXet al

In this study, we identified a metabolically dysfunctional subset of disease-associated CD38-expressing CD4 + T cells before symptom onset in AD which, when targeted in 5xFAD mice, resulted in an improvement of metabolic fitness and cognition