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Disclosures: Elizabeth Williams: Nothing to Disclose, Regina Weber: Nothing to Disclose, Archita Desai: Nothing to Disclose, Raj Vuppalanchi: Nothing to Disclose 1984 UNLOCKING EPHX1-MEDIATED ALTERATIONS IN EICOSATRIENOIC ACID METABOLISM: NOVEL THERAPEUTIC TARGETS IN LIVER FIBROSIS Hiroko Ikenaga 1 Tsutomu Matsubara 1 Masaru Enomoto 1 Misako Sato-Matsubara 1 Le Thi Thanh Thuy 1 NINHQUOC DAT 1 Truong Huu Hoang 1 Ngo Vinh Hanh 1 Chiho Kadono 1 Hideki Fujii 1 Sawako Uchida-Kobayashi 1 Shogo Tanaka 1 Shoji Kubo 1 Takeaki Ishizawa 1 Daisuke Oikawa 1 Fuminori Tokunaga 1 Akihiro Tamori 1 Sergi Guix-Muntet 2 Jordi Gracia-Sancho 2 Frank Gonzalez 3 Kazuo Ikeda 1 Norifumi Kawada 1 , 1 Osaka Metropolitan University, 2 IDIBAPS, 3 National Cancer Institute Background: Chronic liver diseases cause liver fibrosis, which can lead to cirrhosis and cancer

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By various metrics, HDL support mitochondrial function and prevent the release of apoptotic signals, including cytochrome C (205,839)

Adequate protein intake provides amino acids necessary for collagen synthesis