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Description

Basic scientific investigation effort should be geared toward elucidating the biologic mechanisms of PD

22,56,57 Cardiovascular diseases and related risk factors (e.g., hypertension, atherosclerosis) impair blood flow to peripheral nerves, worsening neuropathic symptoms

South Med J 1948

The efficacy of treatments of comorbid pain and depression has been less studied, but it is well known that these two conditions worsen each others severity and therapeutic response