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If you disbelieve the studies (which the failed replications support), then the dose question is moot

This guide provides a comprehensive overview of the process, highlighting key steps and considerations

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(2013) and measures the similarity between two distributions by the integral over the squared difference between the two distribution functions: where F ( t ) and G ( t ) are the empirical cumulative distribution function of the modeled and reference-truth data, respectively, computed following the implementation outlined in Pulkkinen et al