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Biochim Et Biophys Acta (BBA)-Bioenergetics

Also, at higher doses, they can impair athletic performance by elevating body temperature and accelerating muscle breakdown

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This result might have wide implications for human health considering more than 30% of East Asians and over 540 million people worldwide have a dominant negative mutation in ALDH2 that reduces the activity of this enzyme (the ALDH2*2 polymorphism)