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Miplyffas approval was backed by data from a 12-month multicenter, randomized, double-blind, placebo-controlled trial that investigated the treatment in NPC patients 2 to 19 years of age

[1] It has also been studied, in NIH-funded research, for HIV-associated fatty liver disease (NAFLD/MASLD), and earlier in its development program it was investigated for indications as varied as wasting, sleep, and mild cognitive impairment most of which did not advance

Its vital to get enough B12 through diet or supplements, mainly for those at risk of deficiency or with high homocysteine levels

J Exp Bot 60:12071218 Doyle SM, Diamond M, McCabe PF (2010) Chloroplast and reactive oxygen species involvement in apoptotic-like programmed cell death in Arabidopsis suspension cultures