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Well-designed clinical trials and experimental studies would be beneficial for facilitating a better understanding of the mechanism of natural products and promoting the modernization of natural products in the treatment of H

Studies have demonstrated that microglia Hv1 promoted neuronal and oligodendrocyte death and exacerbated brain tissue injury, whereas Hv1 knockout mice exhibit restoration of neuronal number and improvement of neurological function [20,21,22]

Finally, we critically evaluate emerging therapeutic strategies targeting mtROS, including mitochondria-targeted antioxidants and conventional redox-modulating interventions, and discuss their translational potential and current limitations

polygyrus (109, 110), have been shown to exert beneficial effects (such as improvement of glucose tolerance and insulin sensitivity) in various T2D mouse models ( Table 2 )