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Important overlapping endogenous molecular processes of IVD degeneration and facet joint osteoarthritis include extracellular matrix degeneration, inflammation, oxidative stress, apoptosis, senescence and reduced autophagy

Despite low CNS penetration, some studies report detectable levels in the brain, supporting its potential for systemic biological effects without significant accumulation (Jzwiak et al

Individual variability in glycine metabolism, baseline dietary intake, and genetic factors likely influence response

A herniation happens when a tear or crack in that tough outer annulus allows some of the soft nucleus to push through