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As required under section 1860D-14B(b)(1)(C)(iii) of the Act, CMS will reduce the total rebate amount determined under 428.201, if any is owed, for a generic Part D rebatable drug when CMS determines that the generic Part D rebatable drug is likely to be in shortage, as set forth in 428.300

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All the systems were solvated by TIP3P waters (66) by setting the initial edge of the cubic periodic box to a length of 20 nm