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However, the upregulation of SIRT6 inhibits the transcription of Notch1 and Notch4 through deacetylating H3K9 and significantly downregulates the secretion of NLRP3 and the pro-inflammatory factor IL-1, thereby alleviating the inflammatory response, mitigating podocyte damage and glomerulosclerosis (Liu et al., 2017

Gregory Malzberg, MD