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Standard clinical escalation protocol The Phase 2 trial published in the New England Journal of Medicine established the titration schedule that most researchers follow

Low-water cutoffs protect pumps from operating without sufficient water, preventing costly repairs

They didnt fail

However, within a nasal cavity, a rapid mucociliary clearance and enzymatic degradation play an important role in reducing drug stability and brain uptake, while interindividual variability in nasal anatomy and epithelial permeability may contribute to inconsistent therapeutic responses (Wong et al., 2024)