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The Effects of Ketaminehydrochloride and Diazepam on the Intraocular Pressure and Pupil Diameter of the Dog's Eye

In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition

99%+ Purity Verified: Every batch comes back over 99% via HPLC and mass spectrometry

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