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7 Traditional Indian and Chinese medicines have accounted for a number of plant species with distinctive beneficial functions against various diseases

while the exposure of these cells to TiO 2 -NPs (50, 100 and 200 mg/mL/24 h) induced a dosedependent increase in the expression and aggregation of -syn, as well as a reduction of the expressions of Parkin (E3 ligase), and the ubiquitin C-terminal hydrolase ( UCH-L1 ), these events were associated with increased oxidative stress (Wu and Xie, 2014)

Similarly, in young mice subjected to transient focal cerebral ischemia, melatonin demonstrated significant protective effects on the BBB [189, 190]