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NRF2 inhibits inflammation in OA chondrocytes by suppressing the NF-B signaling pathway, promotes the expression of various antioxidant enzymes such as HO-1 and NQO1, thus inhibiting oxidative stress, protecting the cartilage extracellular matrix, reducing aging and death of chondrocytes (including apoptosis, ferroptosis, and pyroptosis), and alleviating joint pain

However, it should be noted that the analgesic drugs that effectively relieve pain symptoms in CIPN and are used as interventional treatments for pre-existing CIPN-related pain are very limited and that their efficacy in CIPN is significantly lower than that observed in other neuropathic pain types

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Boiled Potatoes: Boiling produces a soft texture and mild flavour