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CHRONIC ILLNESSES Infants and children with fever who have known chronic illnesses that affect immune status (e.g., leukemia, sickle cell disease, human immunodeficiency virus infection, cystic fibrosis, diabetes, congenital heart anomalies) may require more aggressive evaluation and management than children without such conditions

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Each unit increase in NRS was also associated with a 2 to 3-unit decline in reported QoL for the remaining dimensions of emotional well-being, general health, physical function, energy/ fatigue, social functioning, and the impact of emotional health