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The results of the study showed that treatment with AGN extract improved the mean weight of the cryptorchid testis, prevented oxidative stress in TM3 cells in a dose-dependent manner, preserved sperm counts, motility, and spermatogenic cell density, reduced 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased superoxide dismutase (SOD) levels, considerably raised Nrf2 and HO-1, as well as substantially lowered apoptosis

We found that pH int was unchanged when the cells were exposed to a low pH condition (Supplementary Fig

In addition, multiple transcription factors, such as ATF3, ATF4, P53, Nrf2, and c-Myc, have been identified as the regulators of SLC7A11 and SLC3A2 transcription [11, 27,28,29,30]