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Shinohe A, et al

& Stankoff, B

The body produces carnitine in the liver, kidneys, and brain from the amino acids lysine and methionine and stores it primarily in the heart and muscle cells

Moreover, the up-regulation of hipoxia factors suppresses the expression of miR-199a-5p and promotes glycolysis in liver cancer, since the miRNA normally interferes with the expression of HK2 (Guo et al., 2015)