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To circumvent this bottleneck, the same group ingeniously exploited the structural similarity between fluorouridine (Fdu) and thymidine, incorporating Fdu during solid-phase synthesis to enable subsequent TME-responsive carbonate linkage with a synergistic PROTAC, yielding AS-2F-NP (Fig

Of particular interest are the findings from studies of participants in

Knockdown of both G3BP1 and G3BP2 in hMDM (G3BP1/2 DKD ) resulted in a reduction of SG formation as evaluated by a key SG marker, eIF4G puncta, during LLOMe treatment (Figs