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The intensity and the distribution level of the staining of TRP-1 and GP100 was higher in the hair follicle melanocytes of fully pigmented follicles, sporadic in melanocytes with reduced pigmentation and lacking in weakly pigmented/white hair follicles (Fig

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The structural difference is a single amino acid substitution at position 1: glycine in GHK-Cu and alanine in AHK-Cu, which is thought to shift the peptide's biological affinity more specifically toward hair follicle cells rather than the broader tissue-repair profile of GHK-Cu