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[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe

This is often the form that is used with injections for B12 deficiencies and as a treatment for cyanide poisoning

10 NNMT protein is highly expressed in aged (28 mo) tibialis anterior (TA) skeletal muscle tissue vs

When vitamin B12 levels are low, myelin production can suffer, leading to communication breakdowns in the nervous system