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These findings were confirmed in 4T1 and HKP1 cell lines (Fig.S2 C, D)

This imbalance contributes to mitochondrial fragmentation, functional impairment, and oxidative stress, all of which exacerbate endothelial cell dysfunction, apoptosis, and impaired wound healing (Sun et al., 2016)

Both chemotherapeutic agents also lead to increased levels of proinflammatory cytokines (IL-6, IL-8, IL1, TNF-), which can lead to sensitization of nociceptors (Ledeboer et al., 2007