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These findings were challenged by a more recent in vitro study, using fecal microbiota from healthy donors (Peng et al., 2024)

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Also, since depressive outcomes were assessed with different rating scales, we grouped them based on the scales most frequently used and performed a secondary meta-analysis within the HDRS (n=9), BDI (n=4), and MADRS (n=3) groups

The experimental protocol involved daily administration of varying BPC157 dosages (540 g/kg) via subcutaneous injection for 7 consecutive days, with parallel saline control groups receiving equivalent volumes