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These limitations are amplified in metastatic disease, where substantial genetic divergence between primary tumors and individual metastatic lesions has been documented across lungs, breast, Squamous Cell Carcinoma (SCC), melanoma, and prostate cancers

10.3390/ijms22020873 151

Tofacitinib also significantly inhibits IL-22-induced CXCL1 and CXCL5 expression in human colonic tissues, suggesting that targeting the IL-22/CXC chemokine axis through JAK/STAT inhibition may be a viable therapeutic strategy

Consistent with the hypothesis that GS dysfunction in astrocytes impairs glutamatergic homeostasis and induces depression-like phenotypes, GS cKO mice exhibited significant anxiety, helplessness, and anhedonia in the OFT, TST, and SPT, respectively (Fig