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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

Due to their higher LET, -particles cause higher tissue damage within a short range of up to 100 m [126]

Knock-out of the Igf2r / M6pr gene combined with Igf2 ko/ Igf1r ko could partly rescue growth retardation, a finding that was explained by IGF-II actions via the insulin receptor (INSR)