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246 RobinsonMMMcBryantSJTsukamotoTRojasCFerrarisDVHamiltonSKet al

OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function

The main characteristics of chronic kidney disease (CKD) include progressive renal tissue structural lesions and impaired renal excretory function, which may be due to functional nephron defects caused by diverse causative variables, including diabetes, interstitial nephritis, glomerulonephritis, obstructive nephropathy and polycystic kidney disease (116)

We discovered that the expression of endogenous MAT2A protein was significantly and progressively upregulated in eNLS-MAT2A(D134A) cells whereas it was reduced in eNLS-MAT2A(WT) cells ( Fig