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In a hypoxic environment, the activity of PHD2 in osteocytes is reduced and HIF signalling is enhanced, improving the activity of the canonical Wnt signalling pathway through the HIF-SIRT1-SOST--catenin signalling axis, thereby promoting bone formation mediated by the activated Wnt/-catenin signalling pathway and inhibiting osteoclast bone resorption mediated by RANKL and OGP

(These drugs are also known as Ozempic and Mounjaro when people take the same medications for diabetes.) And the amount of weight people lost with retatrutide matches or exceeds the amount of weight people lose when they have bariatric weight-loss surgery

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