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The addition of atypical antipsychotics to the field of psychopharmacology has represented a significant advance in the therapy of schizophrenia, providing an effective way to treat the positive and negative symptoms of psychosis

Nevertheless, due to the variety of reactive groups on the protein surface, it is rather challenging to select two different amino acid residues for dual modification that provide orthogonal reactivities and sufficient surface abundance without using non-canonical amino acids 15,16,17,18,19

IGN 's Goldstein accepted that the darker tones to the story were a break from series tradition

In some cases, treatment is altogether unsuccessful and symptoms can be progressive and debilitating (211, 214) and as many as 31% of patients may have worsening symptoms following treatment (211)