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Cell Metab (2019) 30(6):10551074 e8

Numerous studies have indicated that leptin, a crucial hormone involved in the regulation of energy balance and BMI, may be involved in MDD

This transcriptional regulation complements the previously described suppression of pro-inflammatory mediators, such as NO, PGE2, and ROS, and the inhibition of NF-B and JNK signaling pathways

This study identifies aspartate as one such limiting metabolite, and suggests that its availability could be targeted for anti-cancer therapies. Birsoy is a former postdoc in professor of biology David Sabatinis lab, who authored a paper published in the same issue of Nature Cell Biology , identifying aspartate as a major growth limitation in oxygen-deprived tumors