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moreover, it indirectly impacts the brain by impairing the immune system and changing the usual gutbrain link

Plant Physiol 94:13901401 Srivalli S, Khanna-Chopra R (2008) Role of glutathione in abiotic stress tolerance

Nature 536, 479483

4,54 In addition to the RING E3 ligase Pirh2, the WW-domain, HECT-containing, E3 ligase Itch/AIP4 bound within aa 397571 of the SAM domain of p63 and induced its ubiquitination and degradation