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The upregulation of collagen VII was confirmed in human skin explants by immunohistological staining

Molecular mechanisms of GDF11 and MSTN signaling The mature GDF11 and MSTN ligands first bind to activin type 2 receptors (ACVR2A or ACVR2B) and subsequently recruit type 1 receptors, activin receptor-like kinase 4 (ALK4) or ALK5 to form a heteromeric receptor complex to elicit downstream signaling via phosphorylation of SMAD2 and/or SMAD3 (Fig