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Other important constituents also include several isoflavonoid derivatives such as shinpterocarpin, glabrone, glabridin, galbrene, lico-isoflavones A and B (Asl and Hosseinzadeh, Figure 9 Due to their antioxidative properties, several species of Glycyrrhiza were investigated for possible therapeutic effects as neuroprotectants against neurodegenerative disorders such as PD, AD, and dementia

HIF1alpha-dependent uncoupling of glycolysis suppresses tumor cell proliferation

Notably, the optimal in vivo neuroprotective dose was identified as 0.5 mg/kg, which produced substantial behavioral and histological improvements

As outlined in Section 5.1, complementary strategies utilizing hypoxia-preconditioned cells and their derivatives may further potentiate these regenerative processes, highlighting the need for precise regulation to prevent maladaptive outcomes