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Additionally, ROS promote the overactivation of cancer survival pathways, such as STAT-3, signal transducer and activator of transcription 3/VEGF, vascular endothelial growth factor, STAT-3/VEGF, signaling, that promotes angiogenesis [16]

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This might be, at least in part, to the fact that apoptosis was the only mode of cell death that could be examined using marker proteins (caspases and their substrates) as well as electron and fluorescence microscopy when the studies were performed