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2AD), the inhibition capacity of SP on both the synovial inflammation and the osteoclast differentiation makes it an ideal candidate for RA treatment

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Klotho cleavage occurs at a site directly above the plasma membrane (-cut) or between the KL1 and KL2 domain (-cut), resulting in soluble full-length klotho or KL1 and KL2 fragments (97) ( Figure 6 )