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NOs activation of Nrf2 in endothelial cells required an increase in free zinc level intracellularly but how zinc activates Nrf2 is not clear [89]

Elevation of serum copper levels in Alzheimers disease

218 LovellM

In conclusion, UCH-L1, USP22, OTUD5, and USP14 are promising therapeutic targets in DKD, but more clinical studies are needed to confirm safety and efficacy