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Given the benign mechanism of action and the excellent safety profile observed in trials, serious long-term risks seem unlikely

23 Cruz-RamrezA.Daz-TrivioS.BlilouI.GrieneisenV

Abstract A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or good stress and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-B (NF-B), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2related factor 2 (Nrf2) and other processes

Miglioramenti significativi si sarebbero osservati in pazienti affetti da claudicatio itermittens (zoppia intermittente), dislipidemie con aumentato rischio aterosclerotico e patologie vascolari periferiche