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In another series of experiments, apoE3 Christchurch was effective in preventing tau pathology and associated neurodegeneration when human fibrillar tau was injected in an amyloid mouse model of AD [194]

Current evidence does not justify answering yes for everyone

28 When DNA repair pathways become disrupted, particularly those involving base excision repair and nucleotide excision repair, accumulated DNA damage triggers p53-mediated responses, which can induce cell cycle arrest, apoptosis, or premature differentiation of MSCs, directly contributing to the graying phenotype