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Both reactive oxygen species and antioxidants are required for a healthy functioning system, and a tip in the balance towards increased oxidative stress has thus been linked to the development of depression (Correia et al

In CKD patients, serum -tocopherol levels are markedly decreased, suggesting an increased need for -tocopherol in this population [86]

Moreover, ROS, a product of ferroptosis, has been found to accumulate in the damaged gut tissues of infants with necrotizing enterocolitis and to serve as a regulatory point (ROS-NF-B axis) in ameliorating inflammation in necrotizing enterocolitis (141)

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