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Danazol, an older option, carries androgenic effects like acne, hirsutism, and liver dysfunction

Up to this point, we have ignored the fact that some drugs follow more complex multicompartment pharmacokinetics, eg, the distribution process illustrated by the two-compartment model in Figure 32

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To this end, we have chosen 6 kinases from the common set (the JNK3 target, and 5 off-target kinases: INSR, IRAK1, KIT, PDGFRB as off-targets from the JNK-IN-8 study and TNK1 as an off-target from the 1a R -IN-8 study) and an additional kinase, the homolog of TNK1 without a P-loop cysteine (ACK1/TNK2) and had them tested in the Eurofins DiscoverX platform at 1 M concentration with JNK-IN-8, 1a R -IN-8, and 6 S,S -IN-8