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In the formation of TLS, because an enormous number of immune cells are ectopically recruited to nonlymphoid organs, it is speculated that dramatic metabolic remodeling occurs in immune cells in the organ

Ethics declarations Competing interests HAC received research funds from Janssen, Eli Lilly, Fresenius Kabi and Pfizer, but nothing related to the current manuscript

Characterization through 1 H NMR spectroscopy was employed to confirm the chemical structures of the compounds, verifying the successful synthesis of these materials (Figure S26)

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