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Butyrate, functioning both as a histone deacetylase inhibitor and as a ligand for G-protein coupled receptors, can alter gene expression in the brain, preventing neurodegeneration and promoting regeneration ( In our recent publication, we developed a hypothetical but novel argument that there are a small number of organic molecules that may be uniquely configured to support deuterium trapping on carbon atoms (Seneff et al., 2025a)