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81501539), the Natural Science Foundation of Guangdong Province (No

There is still substantial incentive to develop more effective and safe therapeutic strategies

338 A-357300, which was subsequently developed, has shown anticancer activity in mouse models of cancer, sarcoma, and nervous system tumors, 339,340 and another candidate, METAPi A-800141, which was selected based on affinity selection based on mass spectrometry, has better selectivity and efficacy than A-357300