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Pharmacological screening using an FXN-EGFP cellular genomic reporter assay for the therapy of Friedreich ataxia

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Thus, with pathologic HNE concentrations (10M and higher) for rat GCLC, ERK activation was required for the HNE-mediated induction but for human GCLC, JNK activation was essential and Nrf2 was not required (Iles and Liu, 2005)