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In the later stages of bipolar disorder, an imbalance between inflammatory cytokines (especially TNF-alpha), mediators of oxidative stress, and BDNF persists even between episodes and is associated with metabolic disruption, progression of structural brain changes, and neurocognitive decline (85, 215, 231, 235)

Emerging compounds and their hair loss profiles Newer medications in the GLP-1 family and related classes are entering the market

217 Astrocytes play an important role in maintaining extracellular K + homeostasis in the CNS, as well as H + , Cl - , and Ca 2+ homeostassis