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In summary, this study shows that piperine regulates glucose uptake by inducing the lactate-AMPK-p38 MAPK pathways and also causes a mitochondrial respiration regulation via UCP1 induction in skeletal muscle C2C12 cells

Future research should focus on optimizing isolation and purification techniques, developing efficient oral delivery systems, and enhancing the targeting and stability of MEVs through functional modifications

2i), established biomarkers of liver injury, were significantly decreased in mice overexpressing AGXT in hepatocytes

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