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Diabetic complications : Diabetes is associated with glycation of proteins, including enzymes like GR, potentially impairing their function

TP53 can also enhance multienzyme activity to facilitate the accumulation of ROS

Pancreatic Cancer Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor 5-year survival rate (~10%) due to inherent chemoresistance, barriers to drug delivery, and a lack of early diagnostics