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As GSH acts as a major antioxidant in the brain, this impaired GSH redox status can lead to further oxidative damage and redox dysregulation, which is associated with cognitive deficits, neuronal death, and mortality in animal epilepsy models

In contrast, the gdh3 / gdh3 mutant showed overall higher concentrations of intracellular metabolites than the wild-type strain when grown in MM medium, except for 2-aminobutyrate and norvaline.When grown in a proline medium, the gdh3 / gdh3 mutant revealed a significantly higher concentration of glutamate family metabolites (e.g., glutamate, glutamine, and proline) than the wild-type, whilst asparagine, histidine, phenylalanine, valine, leucine, tyrosine, and aspartate family metabolites (e.g., aspartate, isoleucine, and threonine), as well as all saturated fatty acids detected, were at lower concentrations in the gdh3 / gdh3 mutant

omega-3 fatty acids exert more complex bioactive effects, including down-regulation of inflammatory cytokines and also serve as precursors of essential lipid mediators, in particular specialized pro-resolving mediators (SPMs) such as resolvins, protectins and maresins